Sodium thiocyanate → HCID 86650854, compound

Participants

Reaction Steps

17.91 g (120.5 mmol) of 3-chloro-5-methylhexan-2-one were dissolved in 120 ml of methyl ethyl ketone, 10.0 g (123.4 mmol) of sodium thiocyanate were added and the reaction mixture was heated under reflux for 1 h. After cooling, the reaction mixture was filtered, the residue was washed with methyl ethyl ketone and the combined filtrates were concentrated on a rotary evaporator. The oily residue was taken up in about 400 ml of dichloromethane and washed three times with in each case 100 ml of water. The organic phase was dried over sodium sulfate and the solvent was removed on a rotary evaporator. This gave 20.07 g of the crude product, which was reacted further as such.

Provenance & Evidence