反应详情

温度

95 °C

25 ml of 85% strength phosphoric acid were added to 20.07 g (117.26 mmol) of 5-methyl-2-oxohexan-3-yl thiocyanate, and the mixture was heated to 95° C. over a period of 1 h. At a temperature of 95-100° C., the mixture was stirred for another 0.5 h. After cooling, the reaction mixture was added to 40 ml of water and extracted repeatedly with tert-butyl methyl ether. The combined organic phases were washed with water, dried over sodium sulfate and concentrated on a rotary evaporator. This gave 18.11 g of the target compound, which was reacted further without further purification.

1. temperatureAfter cooling
2. extractionextracted repeatedly with tert-butyl methyl ether
3. washThe combined organic phases were washed with water
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated on a rotary evaporator
6. customThis gave 18.11 g of the target compound, which was reacted further without further purification