Hydrochloric Acid → HCID 58136371, compound

Participants

Reaction Steps

1.01 g (2.515 mmol) of methyl cyclopentyl(4-{[4-methyl-5-(2-methylpropyl)-2-oxo-1,3-thiazol-3(2H)-yl]methyl}phenyl)acetate were dissolved in 30 ml of THF, and 10 ml of methanol and 10 ml of 1 N aqueous sodium hydroxide solution were added. The reaction solution was stirred at room temperature for 2 days. A further 5 ml of 1 N aqueous sodium hydroxide solution were then added, and the mixture was stirred at RT for another 2 days. 20 ml of 1 N hydrochloric acid were then added, and the reaction mixture was extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and the solvent was removed on a rotary evaporator. This gave 956 mg (2.47 mmol, 98% of theory) of the target compound.

Provenance & Evidence