Lithium hydroxide, monohydrate → HCID 58136703, compound

Participants

Reaction Conditions

Reaction Steps

86 mg (2.04 mmol) of lithium hydroxide monohydrate were added to a solution of 450 mg (1.02 mmol) of methyl (4-{[2-(4-chlorophenyl)-5-oxo-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl]methyl}phenyl)(cyclopentyl)acetate in 10 ml of dioxane and 10 ml of water, and the mixture was stirred at 80° C. for 12 h. After removal of the dioxane under reduced pressure, the aqueous phase was adjusted to pH 2 using 1 M hydrochloric acid, which resulted in the flocculation of the product. The solution was filtered and the filter residue was dried under reduced pressure. This gave 373 mg (0.87 mmol, 86% of theory) of the title compound as a white solid.

Provenance & Evidence