HCID 58136657, compound → HCID 58136650, compound

Participants

Reaction Steps

41 mg (0.076 mmol) of ethyl (2E)-3-{4-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoyl)amino]phenyl}prop-2-enoate (Example 176A) were dissolved in 17 ml of ethanol, and 75 mg of palladium on carbon (10%) were added. Under an atmosphere of hydrogen, the mixture was hydrogenated at atmospheric pressure for 2 h. The reaction mixture was then filtered through Celite, and the filtrate was concentrated under reduced pressure. This gave 39 mg (95% of theory) of the title compound.

Provenance & Evidence