HCID 58136501, compound → HCID 58136325, compound

Participants

Reaction Steps

130 mg (0.24 mmol) of ethyl (2E)-3-{3-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoyl)amino]phenyl}prop-2-enoate (Example 135A) were dissolved in 10 ml of ethanol, and 10 mg of palladium on carbon (10%) were added. Under an atmosphere of hydrogen, the mixture was hydrogenated at atmospheric pressure overnight. The reaction mixture was then filtered through Celite and the filtrate was concentrated under reduced pressure. This gave 118 mg (0.22 mmol, 90% of theory) of the title compound.

Provenance & Evidence