Cyclohexane ethylacetate → HCID 58136378, compound

Participants

Reaction Steps

At room temperature, 50 mg of platinum on carbon (5%) were added to a solution of 200 mg (0.71 mmol) of tert-butyl(2E)-3-(2-chloro-3-nitrophenyl)prop-2-enoate in 10 ml of ethyl acetate, and the mixture was hydrogenated at atmospheric pressure for 12 hours. After the reaction had gone to completion (monitored by TLC; mobile phase cyclohexane/ethyl acetate 1:1), the reaction solution was filtered through kieselguhr and the filtrate was concentrated under reduced pressure. The crude product was purified by preparative HPLC. This gave 115 mg (0.62 mmol, 64% of theory) of the title compound.

Provenance & Evidence