tert-butyl(+)-cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-ethanoate → (+)-Cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}ethanoic Acid

Participants

Reaction Steps

At RT, 695 mg (1.71 mmol) of tert-butyl(+/−)-cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}acetate were dissolved in 11 ml of a 4 N solution of hydrogen chloride in dioxane, and the mixture was stirred for 12 h. The reaction mixture was then frozen and freeze-dried under high vacuum. This gave 700 mg of product, which was not purified any further.

Provenance & Evidence