Formamide → HCID 22064669, compound

HRID 877235Notes

Reaction equation

HRID 877235 reaction equation
[F:1][C:2]1[C:10]2[C:9](=[O:11])[O:8][C:7](=O)[C:6]=2[C:5]([F:13])=[CH:4][CH:3]=1.C([NH2:16])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([F:13])=[C:6]2[C:10]=1[C:9](=[O:11])[NH:16][C:7]2=[O:8]

Participants

3

Reactant 2

HCID 713FormamideHCID 5139183,6-Difluorophthalic anhydride

Product 1

HCID 22064669HCID 22064669, compound

Procedure

Under argon, 2.15 g (11.68 mmol) of 4,7-difluoro-2-benzofuran-1,3-dione were stirred in 15 ml of formamide at 130° C. for 5 h. The cooled reaction mixture was then added to ice-water. A solid precipitated out. This solid was filtered off with suction and washed with water. The product was dried under high vacuum. This gave 0.45 g (21% of theory) of the target compound.

Workup

  1. customThe cooled reaction mixture
  2. customA solid precipitated out
  3. filtrationThis solid was filtered off with suction
  4. washwashed with water
  5. customThe product was dried under high vacuum

Sources & evidence

ORD record
ord-10acc64a543742be9a63fb7f39b81068
Source dataset
uspto-grants-2015_03
Patent number
US08987256B2

Reaction notes

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