反应详情

A solution of 200.0 mg (0.44 mmol) of tert-butyl(+/−)-cyclopentyl{4-[(4,7-difluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}acetate in 1 ml of ethanol was cooled to 0° C., and 18.3 mg (0.48 mmol) of sodium borohydride were added. 0.2 ml of dichloromethane was added, and the reaction mixture was warmed to RT. After 1 h of stirring, the mixture was concentrated and the residue was purified by chromatography on silica gel (mobile phase cyclohexane/ethyl acetate 6:1 to 4:1). This gave 182 mg (90.6% of theory) of the target compound.

1. concentrationthe mixture was concentrated
2. customthe residue was purified by chromatography on silica gel (mobile phase cyclohexane/ethyl acetate 6:1 to 4:1)