反应详情

90.0 mg (0.20 mmol) of tert-butyl cyclopentyl{4-[(4,7-difluoro-1-hydroxy-3-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}acetate were initially charged in 1 ml of dichloromethane, and 300 μA of trifluoroacetic acid and 62 μl (0.39 mmol) of triethylsilane were added. The mixture was stirred at RT for 2 h. The reaction mixture was then concentrated on a rotary evaporator, the residue was taken up in ethyl acetate and the solution was washed with water and saturated sodium chloride solution. The organic phase was dried over magnesium sulfate and concentrated under reduced pressure. This gave 77.0 mg of the target compound.

1. concentrationThe reaction mixture was then concentrated on a rotary evaporator
2. washthe solution was washed with water and saturated sodium chloride solution
3. dry with materialThe organic phase was dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure