Cesium carbonate → tert-Butyl 3-{3-[(cyclopentyl{4-[(4-methyl-1-oxophthalazin-2(1H)-yl)methyl]phenyl}acetyl)-amino]-2-methylphenyl}propanoate

Participants

Reaction Steps

50 mg (0.097 mmol) of tert-butyl 3-[3-({[4-(bromomethyl)phenyl](cyclopentyl)acetyl}amino)-2-methylphenyl]propanoate, 19 mg (0.12 mmol) of 4-methylphthalazin-1(2H)-one and 47 mg (0.15 mmol) of cesium carbonate were stirred in 5 ml of DMF at 60° C. for 12 h. After cooling, the reaction mixture was purified directly by preparative HPLC. This gave 43 mg (0.07 mmol, 74% of theory) of the racemic title compound.

Provenance & Evidence