Trifluoroacetic acid → HCID 58136477, compound

Participants

Reaction Steps

0.27 ml (3.45 mmol) of trifluoroacetic acid was added dropwise to a solution of 106 mg (0.17 mmol) of tert-butyl 3-{3-[(4-methoxy-3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoyl)amino]-2-methylphenyl}propanoate (Example 170A) in 2 ml of dichloromethane, and the mixture was stirred at room temperature for 3 h. The reaction solution was then concentrated to dryness under reduced pressure. The residue obtained was purified by preparative HPLC. This gave 66 mg (0.12 mmol, 68% of theory) of the title compound as a mixture of diastereomers.

Provenance & Evidence