Hydrochloric Acid → HCID 58136373, compound

Participants

Reaction Steps

11 mg (0.26 mmol) of lithium hydroxide monohydrate were added to a solution of 74 mg (0.13 mmol) of methyl 4-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl)amino]-2-methyl-2,3-dihydro-1H-indene-2-carboxylate (Example 131A) in 2 ml of THF and 1 ml of water, and the mixture was stirred at room temperature for 12 h. The reaction mixture was then adjusted to pH 2 with 1 M hydrochloric acid and extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure. This gave 64 mg (0.11 mmol, 88% of theory) of the title compound as a mixture of diastereomers.

Provenance & Evidence