Hydrochloric Acid → HCID 58136410, compound

Participants

Reaction Steps

32 mg (0.76 mmol) of lithium hydroxide monohydrate were added to a solution of 112 mg (0.19 mmol) of methyl 4-[(5,5,5-trifluoro-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}pentanoyl)amino]-2,3-dihydro-1H-indene-2-carboxylate (Example 143A) in 2 ml of THF and 1 ml of water, and the mixture was stirred at room temperature overnight. The reaction mixture was then adjusted to pH 2 with 1 M hydrochloric acid and extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure. The residue obtained was purified by preparative HPLC. This gave 74 mg (0.13 mmol, 68% of theory) of the title compound as a mixture of diastereomers.

Provenance & Evidence