Hydrochloric Acid → HCID 58136411, compound

Participants

Reaction Steps

94 mg (2.25 mmol) of lithium hydroxide monohydrate were added to a solution of 600 mg (1.12 mmol) of methyl 3-{3-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoyl)amino]cyclohexyl}propanoate (Example 142A) in 15 ml of THF and 15 ml of water, and the mixture was stirred at room temperature overnight. The reaction mixture was then adjusted to pH 2 with 1 M hydrochloric acid and extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and then concentrated to dryness under reduced pressure. This gave 573 mg (1.10 mmol, 98% of theory) of the title compound as a mixture of isomers.

Provenance & Evidence