Lithium hydroxide, monohydrate → HCID 44513411, compound

Participants

Reaction Steps

100 mg (2.39 mmol) of lithium hydroxide monohydrate were added to a solution of 339 mg (0.60 mmol) of methyl 2-methyl-4-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}pentanoyl)amino]-2,3-dihydro-1H-indene-2-carboxylate (Example 160A) in 12 ml of THF and 6 ml of water, and the mixture was stirred at room temperature overnight. After the reaction had gone to completion, the THF was removed under reduced pressure and the reaction solution was diluted with water and then adjusted to pH 2 with 1 M hydrochloric acid. The precipitated solid was filtered off, washed with water and dried under reduced pressure at 45° C. overnight. This gave 305 mg (0.55 mmol, 92% of theory) of the title compound as a mixture of isomers.

Provenance & Evidence