Trifluoroacetic acid → HCID 58136471, compound

Participants

Reaction Steps

1.74 ml (22.56 mmol) of trifluoroacetic acid were added to a solution of 460 mg (0.75 mmol) of tert-butyl 3-{2-methyl-3-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}hexanoyl)amino]phenyl}propanoate (Example 163A) in 10 ml of dichloromethane, and the mixture was stirred at room temperature for 2 h. The reaction mixture was then concentrated to dryness under reduced pressure. This gave 410 mg (0.74 mmol, 98% of theory) of the title compound as a mixture of isomers.

Provenance & Evidence