Hydrochloric Acid → HCID 66933216, compound

Participants

Reaction Steps

827 mg (1.461 mmol) of ethyl (2E)-3-{3-[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl)amino]phenyl}prop-2-enoate (Example 174A) were dissolved in 28 ml of dioxane/water (3:1 v/v), and 2.2 ml of 1 N aqueous sodium hydroxide solution were added. The reaction mixture was stirred at room temperature overnight. The reaction mixture was then acidified to pH 1 with 1 N hydrochloric acid and extracted repeatedly with ethyl acetate. The combined organic phases were washed with saturated sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure. This gave 780 mg (95% of theory) of the target compound.

Provenance & Evidence