Sodium Hydroxide → HCID 44513413, compound

Participants

Reaction Steps

0.55 ml (1.11 mmol) of 2 M aqueous sodium hydroxide solution was added to a solution of 31 mg (55 μmol) of ethyl 4-{[(cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl)amino]methyl}cyclohexanecarboxylate (Example 127A) in 3 ml of dioxane, and the mixture was stirred at room temperature overnight. The reaction mixture was then extracted once with tert-butyl methyl ether. The aqueous phase was then adjusted to pH 2 with 1 M hydrochloric acid and extracted twice with ethyl acetate. The ethyl acetate phases were combined and dried over sodium sulfate. After filtration, the solvent was removed to dryness. This gave 25 mg (47 μmol, 85% of theory) of the title compound as a colorless solid.

Provenance & Evidence