Triethylamine → HCID 70660125, compound

Participants

Reaction Steps

353 mg N*4*-[2-(5-Chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine (cf. Example 7) dissolved in 60 ml THF and 330 mg triethylamine were hydrogenated over 1.8 g Pd—C (52% water) over night, at normal pressure and ambient room temperature to give after filtration, evaporation and subsequent digeration with ether 238 mg yellow powder product with correct mass M+H+331 and >90% HPLC purity with a Rt˜1.23 min in LC-MS system 1. TLC on silica in CH2Cl2/MeOH 1:1 showed one product at Rf˜0.21.

Provenance & Evidence