HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → HCID 131732595, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 52919131 | HCID 52919131 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131732595 | HCID 131732595 | — |
Reaction Steps
N*4*-[2-(5-Chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine (cf. Example 7) was treated in THF with CDI and DIPEA over night at ambient temperature. After work up the urea derivative was isolated with correct mass M+H+ 391 and Rt˜1.78 min in LC-MS system 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987301B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cbf6f877343f4242ba66d24b9099bc23 |
| Source note | uspto-grants-2015_03 |