(R)-Quinuclidin-3-yl ((S)-(3-(2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethoxy)phenyl)(phenyl)methyl)carbamate → (R)-Quinuclidin-3-yl ((S)-(3-(2-((4-formylphenyl)amino)-2-oxoethoxy)phenyl)-(phenyl)methyl)carbamate

HRID 877340Notes

Reaction equation

HRID 877340 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:38])[NH:11][C@H:12]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][C:27]([NH:29][C:30]3[CH:35]=[CH:34][C:33]([CH2:36][OH:37])=[CH:32][CH:31]=3)=[O:28])[CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:2]2>O1CCOCC1.[O-2].[Mn+4].[O-2]>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:38])[NH:11][C@H:12]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][C:27]([NH:29][C:30]3[CH:31]=[CH:32][C:33]([CH:36]=[O:37])=[CH:34][CH:35]=3)=[O:28])[CH:20]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:2]2

Participants

4

Reactant 1

HCID 90204880(R)-Quinuclidin-3-yl ((S)-(3-(2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethoxy)phenyl)(phenyl)methyl)carbamate

Product 1

HCID 90211965(R)-Quinuclidin-3-yl ((S)-(3-(2-((4-formylphenyl)amino)-2-oxoethoxy)phenyl)-(phenyl)methyl)carbamate

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of (R)-quinuclidin-3-yl((S)-(3-(2-((4-(hydroxymethyl)-phenyl)amino)-2-oxoethoxy)phenyl)(phenyl)methyl)carbamate (0.68 g, 1.31 mmol) in 1,4-dioxane (10 mL) was added manganese (IV) oxide (0.57 g, 6.58 mmol). The reaction mixture was stirred at room temperature for 60 hours. The suspension was filtered and the filter cake was washed with ethyl acetate. The filtrate was evaporated at reduced pressure to afford the crude title compound. This material was used without further purification.

Workup

  1. filtrationThe suspension was filtered
  2. washthe filter cake was washed with ethyl acetate
  3. customThe filtrate was evaporated at reduced pressure

Sources & evidence

ORD record
ord-4904d3921e3948118c3faa0115b0b5fa
Source dataset
uspto-grants-2015_03
Patent number
US08987299B2

Reaction notes

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