HCID 68156576, compound → HCID 178440885, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-tert-butylphenyl)-N-{(S)-[1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl][5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}acetamide (0.064 g, 0.11 mmol) was dissolved in TFA (1.0 mL) and heated at 65° C. for 6 h. The solvent was removed by N2 and the residue was purified by reverse-phase HPLC to give the product (0.046 g, 91%). 1H NMR (CDCl3, 400 MHz) δ 8.30 (d, J=2.8 Hz, 1H), 7.94 (d, J=6.8 Hz, 1H), 7.49 (s, 1H), 7.45 (d, J=8.8 Hz, 1H), 7.39 (dd, J=2.8, 8.8 Hz, 1H), 7.34 (d, J=8.4 Hz, 2H), 7.20 (d, J=8.4 Hz, 2H), 6.39 (d, J=6.8 Hz, 1H), 4.41 (q, J=8.0 Hz, 2H), 3.63 (s, 2H), 1.30 (s, 9H). HRMS (ES) [M+1]+ calcd for C22H24F3N5O2: 448.1955. Found: 448.1976.

Provenance & Evidence