1-Amino-2-propanol → HCID 86668962, compound

Participants

Reaction Steps

A mixture of CDI (19 g, 0.12 mol), Boc-D-alanine (20 g, 0.11 mol) and DCM (300 ml), was stirred at r.t. for 1 h, before 1-amino-2-propanol (14 ml, 0.18 mol) was added. The reaction mixture was stirred at r.t. overnight. After concentration, the residue was purified by column, and 13 g (46.3%) of N2-(tert-butoxycarbonyl)-N-(2-hydroxypropyl)-D-alaninamide as solid was obtained. ES-MS [M+1]+: 247.01.

Provenance & Evidence