Lawesson's reagent → HCID 86668964, compound

Participants

Reaction Steps

Lawesson's Reagent (14 g, 35 mmol) was added to a solution of N2-(tert-butoxycarbonyl)-N-(2-oxopropyl)-D-alaninamide (8.5 g, 34.5 mmol) in THF (300 ml), and the resulting mixture was refluxed for 6 h. After concentration, the residue was purified by column, and 2.8 g of tert-butyl [(1R)-1-(5-methyl-1,3-thiazol-2-yl)ethyl]carbamate was obtained as solid (35%). 1H-NMR CDCl3 δ 7.31 (s, 1H), 5.24 (br, 1H), 5.00 (m, 1H), 2.42 (s, 3H), 1.55 (d, J=6.8 Hz, 3H), 1.44 (s, 9H) ES-MS [M+1]+: 243.14.

Provenance & Evidence