Hydrochloride methanol → HCID 68156438, compound

Participants

Reaction Steps

tert-butyl [(1R)-1-(5-methyl-1,3-thiazol-2-yl)ethyl]carbamate (2.8 g, 11.5 mmol) was dissolved into HCl-MeOH (40 ml), and the resulting mixture was stirred at r.t. for 2 h. After concentration to remove most of solvent, to the residue was added fresh ethanol, and the residue was concentrated again. The crude product was recrystallized from ethanol and ether to give 1.8 g (87.8%) of (1R)-1-(5-methyl-1,3-thiazol-2-yl)ethanamine hydrochloride as solid hydrochloric salt. 1H-NMR DMSO δ 8.76 (br, 3H), 7.52 (s, 1H), 4.69 (m, 1H), 1.56 (d, J=6.8 Hz, 3H). ES-MS [M+1]+: 143.25.

Provenance & Evidence