Methyl iodide → HCID 52932155, compound

Participants

Reaction Steps

To a solution 2-(4-isopropylphenyl)-N-[phenyl(1H-tetrazol-5-yl)methyl]acetamide (34.0 mg, 0.101 mmol) in 0.5 ml of anhydrous DMF was added K2CO3 (14.0 mg, 0.101 mmol) and MeI (0.006 ml, 0.101 mmol). The resulting solution was stirred at RT for 3 hour. Filtered and the residue was purified by preparative HPLC (5-90% CH3CN/H2O over 30 min, 0.05% added TFA, C18 column) to afford 8.0 mg (23%) of the title compound. 1H NMR (CDCl3, 400 MHz) δ 7.342 (m, 3H); 7.226 (m, 2H), 7.172 (ABq, J=8.2 Hz, 4H), 6.894 (br d, J=7.6 Hz, 1H), 6.424 (d, J=7.9 Hz, 1H), 3.910 (s, 3H), 3.587 (s, 2H), 2.888 (sept, J=7.0 Hz, 1H), 1.234 (d, J=7.0 Hz, 6H). ES-MS [M+1]+: 350.2.

Provenance & Evidence