Tetrahydrofuran → HCID 67171101, compound

Participants

Reaction Conditions

Reaction Steps

To a 25 ml round bottom flask containing −78° C. solution of 2-methyl-N-((1E)-{1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methylene)propane-2-sulfinamide (0.286 g, 0.998 mmol) in 4.0 ml of CH2Cl2 was added dropwise 0.5N 3,4-difluorophenylmagnesium bromide in THF (4.990 ml, 1.495 mmol). The resulting solution was stirred at −78° C. for 30 min, then −20° C. for 16 hours. The reaction mixture was quenched with saturated NH4Cl and extracted with CH2Cl2. The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuum to give the crude title compound as a light yellow liquid (0.498 g, 93% crude). ES-MS [M+1]+: 401.1. This intermediate was carried over to the next step without further purifications and characterizations.

Provenance & Evidence