HCID 178499162, compound → HCID 178520585, compound

Participants

Reaction Steps

The title compound was prepared by methyl ester hydrolysis and spontaneous decarboxylation from ketone 14h (9.0 mg, 0.03 mmol) following general procedure A. Preparative thin layer chromatography (SiO2, 100% EtOAc) afforded the title compound (4.5 mg, 52%) as a colorless oil: 1H NMR (CDCl3, 600 MHz) δ 8.47 (br s, 1H), 7.27 (m, 2H), 7.17 (m, 3H), 3.15 (t, 2H, J=7.4 Hz), 2.61 (t, 2H, J=7.7 Hz), 1.78 (m, 2H), 1.64 (m, 2H), 1.42 (m, 4H); 13C NMR (CDCl3, 150 MHz) δ 194.3, 157.2, 147.5, 142.8, 128.5, 128.4, 125.8, 39.7, 36.0, 31.4, 29.9, 29.2, 23.7; HRMS-ESI-TOF m/z 258.1599 ([M−H]−, C15H19N3O requires 258.1606).

Provenance & Evidence