HCID 44577826, compound → HCID 44577825, compound

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Reaction Steps

The title compound was prepared from 36 (22 mg, 0.052 mmol) following general procedure B. Flash chromatography (SiO2, 5% MeOH—CH2Cl2) afforded the title compound (10.2 mg, 47%) as a white solid: 1H NMR (CDCl3, 600 MHz) δ 8.39 (d, 1H, J=7.8 Hz), 8.25 (d, 1H, J=7.8 Hz), 8.02 (t, 1H, J=7.8 Hz), 7.59-7.54 (m, 4H), 7.44 (t, 2H, J=7.8 Hz), 7.36-7.30 (m, 2H), 4.19 (s, 2H), 4.02 (s, 3H), 3.93 (s, 2H); 13C NMR (CDCl3, 150 MHz) δ 199.1, 164.7, 164.1, 162.1, 148.5, 143.5, 140.5, 140.4, 138.4, 131.4, 129.9, 128.7, 127.7, 127.4 (2C), 127.1, 127.0 (2C), 126.1, 53.2, 49.4, 38.9; HRMS-ESI-TOF m/z 414.1460 ([M+H]+, C24H19N3O4 requires 414.1448).

Provenance & Evidence