反应详情

To a stirred solution of 3-(methylsulfonyl)benzoic acid (1) (1.5 g, 7.5 mmol) in methanol (25 mL) sulfuric acid (1.5 mL) was added and the reaction mixture was heated to reflux for 8 h. On completion, solvent was removed, diluted with water (40 mL) and extracted with ethyl acetate (60 mL×3). The combined organic layer was washed saturated sodium bicarbonate solution, brine, dried over sodium sulphate and concentrated to afford the title compound 2 (1.6 g, 99%) which was used for further reaction.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 8 h
3. customOn completion, solvent was removed
4. additiondiluted with water (40 mL)
5. extractionextracted with ethyl acetate (60 mL×3)
6. washThe combined organic layer was washed saturated sodium bicarbonate solution, brine
7. dry with materialdried over sodium sulphate
8. concentrationconcentrated