HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 877436Generated: October 29, 2026
2-Chlorophenylhydrazine hydrochloride → methyl 1-(2-chlorophenyl)-5-(furan-2-yl)-1H-pyrazole-3-carboxylate
https://huagongshe.com/reaction/877436
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorophenylhydrazine hydrochloride | HCID 443287 | — |
| Reactant | Methyl 4-(furan-2-yl)-2,4-dioxobutanoate | HCID 2771615 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl 1-(2-chlorophenyl)-5-(furan-2-yl)-1H-pyrazole-3-carboxylate | HCID 43513895 | 80% |
Reaction Steps
A stirred solution compound 5 (10.0 g, 50 mmol) and (2-chlorophenyl)hydrazine hydrochloride (10.0 g, 56 mmol) in methanol 80 mL was heated to reflux for 6 h. On cooling to 0° C., solid crashed out, filtered and washed with cold methanol to afford the title compound 6 (12.0 g, 80.0%) which was used for further reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987318B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-703c3e6eccc94c9688814495f9212eee |
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| Source note | uspto-grants-2015_03 |
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