1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → methyl 1-(2-chlorophenyl)-5-(2-(3-(methylsulfonyl)benzoyl) hydrazinecarbonyl)-1H-pyrazole-3-carboxylate

Participants

Reaction Steps

To a stirred solution of compound 7 (500 mg, 1.78 mmol) in DMF (20 mL at 0° C., EDCI (500 mg, 2.6 mmol) was added and stirred for 15 min. HOBt (351 mg, 2.6 mmol) was added to the reaction mixture and after 30 min stirring 3-(methylsulfonyl)benzohydrazide 3 from Example 1 (450 mg, 2.1 mmol) was added. Reaction mixture was allowed to attain room temperature and stirred for over night. Water (100 mL) was added to the reaction mixture and extracted with ethyl acetate (50 mL×4). Combined organic layer was washed with water, brine, dried over sodium sulphate and concentrated. The crude product on column chromatographic purification using 2% methanol in dichloromethane afforded the title compound 8 (452 mg, 52%).

Provenance & Evidence