N-bromobutanimide → HCID 136500851, compound

HRID 877442Notes

Reaction equation

[Br:1]N1C(=O)CCC1=O.[CH3:9][S:10]([C:13]1[CH:14]=[C:15]([C:19]2[NH:23][C:22]([C:24]3[N:28]([CH2:29][C:30]([O:32][CH2:33][S:34][CH3:35])=[O:31])[N:27]=[C:26]([C:36]([F:39])([F:38])[F:37])[CH:25]=3)=[CH:21][CH:20]=2)[CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11]>>[Br:1][C:25]1[C:26]([C:36]([F:39])([F:38])[F:37])=[N:27][N:28]([CH2:29][C:30]([O:32][CH2:33][S:34][CH3:35])=[O:31])[C:24]=1[C:22]1[NH:23][C:19]([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([S:10]([CH3:9])(=[O:12])=[O:11])[CH:14]=2)=[CH:20][CH:21]=1

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 136500857HCID 136500857, compound

Product 1

HCID 136500851HCID 136500851, compound

Procedure

Following bromination with N-bromosuccinimide, the title compound 32 is prepared starting from methylthiomethyl 2-(5-(5-(3-(methylsulfonyl)phenyl)-1H-pyrrol-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate 31.

Sources & evidence

ORD record: ord-1f430329716e4efc98459b83a2cd9e82
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987318B2

Reaction notes

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