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A mixture of compound 44 (4 g, 14.0 mmol), ethyl 2-hydrazinylacetate (2.37 g, 15.0 mmol) and methanol (60 mL) was heated for 1.5 h. The reaction mixture was cooled to 0° C. and solvent was removed under reduced pressure. Water (100 mL) was added and the reaction mixture extracted with ethyl acetate (50 mL×3). Combined organic layer was washed with brine, dried over sodium sulphate and concentrated under reduced pressure. The crude compound was purified by column chromatography using 10% ethyl acetate in n-hexane as an eluent to afford the separated isomer 45 (1.2 g, 24%).

1. temperaturewas heated for 1.5 h
2. customsolvent was removed under reduced pressure
3. additionWater (100 mL) was added
4. extractionthe reaction mixture extracted with ethyl acetate (50 mL×3)
5. washCombined organic layer was washed with brine
6. dry with materialdried over sodium sulphate
7. concentrationconcentrated under reduced pressure
8. customThe crude compound was purified by column chromatography