Trifluoroacetic acid → HCID 67377640, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 5,6-dichloro-1-oxo-3,4-dihydro-1H-carbazole-9(2H)-carboxylate (intermediate 1b) (0.9 g, 2.5 mmol) was dissolved in DCM (15 mL), cooled to 0° C., and TFA (1.6 mL) was added. The reaction mixture was stirred at 0° C. for 1 h, neutralized with saturated NaHCO3 (20 mL) and extracted with DCM (2×20 mL). The combined organic extracts were dried over Na2SO4 and concentrated in vacuo to give the title compound as a white solid (450 mg, 70%) which was directly in the next step without further purification. 1H NMR (500 MHz, CDCl3, δ in ppm) 9.18 (bs, 1H), 7.38 (d, J=9.0 Hz, 1H), 7.28 (d, J=9.5 Hz, 1H), 3.37 (t, J=6.0 Hz, 2H), 2.67 (t, J=7.0 Hz, 2H), 2.30-2.25 (m, 2H).

Provenance & Evidence