Trifluoroacetic acid → HCID 67377734, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 7-chloro-6-fluoro-1-oxo-3,4-dihydro-1H-carbazole-9(2H)-carboxylate (0.55 g, 1.6 mmol) was dissolved in DCM (10 mL), cooled to 0° C., and TFA (1 mL) was added slowly. The reaction mixture was brought to room temperature and stirred for 5 h, neutralized with saturated NaHCO3 (10 mL) and extracted with DCM (3×10 mL). The combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure to obtain the title compound (0.35 mg, 92%) which was used in the next step with out any purification. 1H NMR (200 MHz, DMSO-d6, δ in ppm) 11.84 (bs, 1H), 7.76 (d, J=9.8 Hz, 1H), 7.52 (d, J=6.2 Hz, 1H), 2.95 (t, J=6.0 Hz, 2H), 2.60 (t, J=5.8 Hz, 2H), 2.20 (m, 2H).

Provenance & Evidence