Potassium Hydroxide → HCID 52945095, compound

Participants

Reaction Steps

6,8-Dichloro-2,2-difluoro-1-(trifluoromethyl)-1-(trimethylsilyloxy)-2,3,4,9-tetrahydro-1H-carbazole (0.12 g, 0.27 mmol) was dissolved in THF (5 mL) and KOH (0.055 g, 1.1 mmol) in water (5 mL) was added. The reaction mixture was stirred at room temperature for 2 h, diluted with water (10 mL) and extracted with EtOAc (2×50 mL). The combined organic extracts were dried over Na2SO4, concentrated under reduced pressure to give the crude material which was purified by column chromatography [EtOAc-hexane (1:9) as eluant] to furnish the title compound. (0.012 g, 12%). 1H NMR (500 MHz, CDCl3, δ in ppm) 8.41 (br s, 1H), 7.44 (s, 1H), 7.3 (s, 1H), 3.35 (br s, 1H), 2.97 (t, J=12.0 Hz, 2H), 2.61-2.54 (m, 2H).

Provenance & Evidence