Sodium Hydroxide → 2-Oxocyclohexanecarboxylic acid

HRID 877488Notes

Reaction equation

HRID 877488 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:8]([O:10]CC)=[O:9].[OH-].[Na+]>O>[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 95543Ethyl 2-oxocyclohexanecarboxylate

Product 1

HCID 99421712-Oxocyclohexanecarboxylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

Ethyl 2-oxocyclohexanecarboxylate (2 g, 11.7 mmol) was dissolved in water (2 mL), cooled to 0° C. and 5N aqueous .NaOH (5 mL) was added, cooled to room temperature and stirred for 12 h. The reaction mixture was cooled to 0° C., acidified with conc. (pH=2) and used in the next step without any purification.

Workup

  1. temperaturecooled to room temperature
  2. temperatureThe reaction mixture was cooled to 0° C.
  3. customused in the next step without any purification

Sources & evidence

ORD record
ord-3375a37827f8448894a123219513572a
Source dataset
uspto-grants-2015_03
Patent number
US08987319B2

Reaction notes

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