Potassium Hydroxide → HCID 53356866, compound

Participants

Reaction Steps

5,6,7-Trichloro-1-(trifluoromethyl)-1-(trimethylsilyloxy)-2,3,4,9-tetrahydro-1H-carbazole (0.11 g, 0.25 mmol) was dissolved in THF (5 mL) and a solution of KOH (0.050 g, 1 mmol) in water (5 mL) was added. The reaction mixture was stirred at room temperature for 1 h, diluted with water (10 mL) and extracted with EtOAc (2×50 mL). The combined organic extracts were dried over Na2SO4, concentrated under reduced pressure. The crude residue was purified by silica gel column chromatography [EtOAc-hexane (1:9) as eluant] to furnish the title compound (0.09 g, 44%). 1H NMR (500 MHz, CDCl3, δ in ppm) 8.28 (bs, 1H), 7.42 (s, 1H), 3.29-3.23 (m, 1H), 3.02-2.95 (m, 1H), 2.44 (s, 1H), 2.26-2.22 (m, 1H), 2.09-1.98 (m, 3H).

Provenance & Evidence