Ethyl 2-oxocyclohexanecarboxylate → 2-Oxocyclohexanecarboxylic acid

Participants

Reaction Steps

To ethyl 2-oxocyclohexanecarboxylate (3 g, 19.2 mmol) in H2O (10 mL), 5N NaOH (4.5 mL) was added. The reaction mixture was stirred at room temperature for 12 h. The reaction mixture was washed with EtOAc (3×20 mL), the aqueous layer was cooled to 0° C., acidified with conc. HCl (5 mL) (pH-2) to give the crude acid (2.46 g) which was used in the next step without purification.

Provenance & Evidence