Lithium Bromide → HCID 52941376, compound

Participants

Reaction Conditions

Reaction Steps

2-Benzyl-2-bromo-5,6-dichloro-2,3,4,9-tetrahydro-1H-carbazol-1-one (0.48 g, 1.14 mmol) was dissolved in DMF (4 mL) and LiBr (0.1 g, 1.25 mmol) followed by Li2CO3 (0.09 g, 1.25 mmol) were added. The reaction mixture was heated to 90° C. for 1 h, then cooled to room temperature, diluted with water and extracted with EtOAc (3×20 mL). The combined organic extracts were dried over Na2SO4 and concentrated in vacuo to give the crude compound which was purified by column chromatography [EtOAc-hexane (3:17) as eluant] to provide the title compound as a light green solid (0.215 g, 56%). 1H NMR (500 MHz, DMSO-d6, δ in ppm) 11.31 (s, 1H), 9.22 (s, 1H), 7.88 (d, J=8.5 Hz, 1H), 7.52 (s, 2H), 7.26-7.23 (m, 4H), 7.18-7.20 (m, 1H), 6.97 (d, J=8.0 Hz, 1H), 4.14 (s, 2H).

Provenance & Evidence