Lithium Bromide → HCID 52948638, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-benzyl-2-bromo-6,7-dichloro-2,3,4,9-tetrahydro-1H-carbazol-1-one (0.3 g, 0.71 mmol) in anhydrous DMF (5 mL), LiBr (68 mg, 0.78 mmol) followed by Li2CO3 (52 mg, 0.71 mmol) were added. The reaction mixture was heated to 90° C. for 1 h, cooled to room temperature and diluted with water. The reaction mixture was extracted with EtOAc (3×20 mL) to obtain the crude material which was purified by silica gel chromatography [EtOAc-hexane (3:17) as eluant] to give the title compound as a light brown solid (0.07 g, 30%). 1H NMR (500 MHz, DMSO-d6, δ in ppm) 10.98 (s, 1H), 9.18 (s, 1H), 8.29 (s, 1H), 7.74 (s, 1H), 7.59 (d, J=8.0 Hz, 1H), 7.26-7.25 (m, 4H), 7.24-7.23 (m, 1H), 6.92 (d, J=8.0 Hz, 1H), 4.11 (s, 2H).

Provenance & Evidence