HCID 89689588, compound → HCID 89689796, compound

HRID 877540Notes

Reaction equation

HRID 877540 reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([NH:10][C:11]3[CH:18]=[C:17]([NH:19][CH:20]([CH3:22])[CH3:21])[C:14]([C:15]#[N:16])=[CH:13][N:12]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[S:23]=S.[NH4+]>CO>[S:1]1[C:5]2[CH:6]=[C:7]([NH:10][C:11]3[N:12]=[CH:13][C:14]([C:15](=[S:23])[NH2:16])=[C:17]([NH:19][CH:20]([CH3:22])[CH3:21])[CH:18]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 89689588HCID 89689588, compoundHCID 131732601HCID 131732601, compound

Product 1

HCID 89689796HCID 89689796, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a stirred solution of 6-(benzo[d]thiazol-6-ylamino)-4-(isopropylamino)nicotinonitrile (19) (30 mg, 0.09 mmol) in MeOH (2 mL), ammonium thiosulfide (5 mL) was added. The reaction mixture was heated at 60° C. in a pressure tube overnight. The reaction mixture was then evaporated to remove excess of solvent. The crude material was purified by column chromatography through silica gel and MeOH: CHCl3 as eluent to afford 6-(benzo[d]thiazol-6-ylamino)-4-(isopropylamino)pyridine-3-carbothioamide.

Workup

  1. customThe reaction mixture was then evaporated
  2. customto remove excess of solvent
  3. customThe crude material was purified by column chromatography through silica gel and MeOH

Sources & evidence

ORD record
ord-66f4b0e7b17a42e28912e38da0c727a3
Source dataset
uspto-grants-2015_03
Patent number
US08987311B2

Reaction notes

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