Water → HCID 89689763, compound

HRID 877563Notes

Reaction equation

HRID 877563 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[C:11]([C:13](NCCCN3CCCCC3)=[O:14])[N:12]=2)=[C:4]([NH:25][CH:26]([CH3:28])[CH3:27])[CH:3]=1.C(#N)C.[OH2:32]>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[C:11]([C:13]([OH:14])=[O:32])[N:12]=2)=[C:4]([NH:25][CH:26]([CH3:28])[CH3:27])[CH:3]=1

Participants

4

Reactant 3

HCID 962Water2×HCID 6342Acetonitrile2×HCID 89689758HCID 89689758, compound

Product 1

HCID 89689763HCID 89689763, compound

Procedure

[2-(6-Chloro-4-(isopropylamino)pyridin-3-yl)-N-(3-(piperidin-1-yl)propyl)oxazole-4-carboxamide (40b)]: Ascentis Express C18, 5×2.1 mm, 2.7 μm; Solvent A=2% ACN: 98% H2O: 10 mM NH4COOH; Solvent B=98% ACN: 2% H2O: 10 mM NH4COOH; gradient 0-100% B over 1.5 min; retention time: 1.622 min; LCMS (ES-API), m/z 406.2 (M+H).

Sources & evidence

ORD record
ord-e63f7008bc6440cb950917e142319239
Source dataset
uspto-grants-2015_03
Patent number
US08987311B2

Reaction notes

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