참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | Methyl 4-(morpholin-4-ylsulfonyl)benzoate | HCID 809900 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(Morpholinosulfonyl)benzohydrazide | HCID 864339 | 74% |
반응 단계
Methyl 4-(morpholinosulfonyl)benzoate (135 mg, 0.473 mmol) was added to the hydrazine (30.3 mg, 0.946 mmol) in methanol and refluxed for 8 h at 65° C. Following cooling, reaction was monitored by TLC. After completion of the reaction, the solvent was removed by vacuum and then compound was purified by flash chromatography (3% methanol/DCM) to yield the 4-(morpholinosulfonyl)benzohydrazide (102 mg, 0.350 mmol, 74.0% yield) as a white solid. 1H NMR (CDCl3, 400 MHz): δ 7.94 (m, 2H), 7.79 (m, 2H), 3.72 (m, 4H), 2.99 (m, 4H). Mass [M+H]+:286.0
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08987335B2 |
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| 출처 데이터셋 | uspto-grants-2015_03 |
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| ORD ID | ord-a4b4645566c543628626bf034a071288 |
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| 출처 메모 | uspto-grants-2015_03 |
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