Methanol → HCID 31699716, compound

HRID 877651Notes

Reaction equation

HRID 877651 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])(=[O:10])=[O:9])[CH2:4][CH2:3]1.S(=O)(=O)(O)O.[CH3:25]O>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([O:16][CH3:25])=[O:15])(=[O:10])=[O:9])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1081456380339-63-9

Product 1

HCID 31699716HCID 31699716, compound

Procedure

3-((4-methylpiperazin-1-yl)sulfonyl)benzoic acid (250 mg, 0.879 mmol) was refluxed in the presence of concentrated sulfuric acid (5.68 mg, 0.044 mmol) in methanol at 70° C. for overnight. Reaction was monitored by TLC. After completion of the reaction, solvent was removed by vacuum and the crude material was used for further reaction without purification.

Workup

  1. customReaction
  2. customAfter completion of the reaction, solvent
  3. customwas removed by vacuum
  4. customthe crude material was used for further reaction without purification

Sources & evidence

ORD record
ord-e6a8ab16811f44fb9c9c6f9321fab7e5
Source dataset
uspto-grants-2015_03
Patent number
US08987335B2

Reaction notes

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