Hydrochloric Acid → 4-(((3S,4S)-4-ethylpyrrolidin-3-yl)amino)-6-(3-methylisoxazol-5-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

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Reaction Steps

To a solution of (3S,4S)-tert-butyl 3-((3-carbamoyl-6-(3-methylisoxazol-5-yl)pyrrolo[1,2-b]pyridazin-4-yl)amino)-4-ethylpyrrolidine-1-carboxylate (62 mg, 0.136 mmol) in dichloromethane (1 mL) was added 4N HCl in 1,4-dioxane (0.512 mL, 2.046 mmol). After stirring at room temperature overnight, the deprotection was complete. The volatile were removed in vacuo to afford the hydrochloride salt of the title compound (52 mg, 98% yield) as an off-white solid. MS (ES+) m/z: 355.1 (M+H).

Provenance & Evidence