Hydrochloric Acid → 4-(((3S,4S)-4-ethylpyrrolidin-3-yl)amino)-6-(1-phenyl-1H-1,2,3-triazol-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

Participants

Reaction Steps

To a solution of (3S,4S)-tert-butyl 3-((3-carbamoyl-6-(1-phenyl-1H-1,2,3-triazol-4-yl)pyrrolo[1,2-b]pyridazin-4-yl)amino)-4-ethylpyrrolidine-1-carboxylate (41 mg, 0.079 mmol) in dichloromethane (1 mL) was added 4N HCl in 1,4-dioxane (0.198 mL, 0.794 mmol). The solution was stirred at room temperature. After stirring 2 h, the reaction is complete. Concentration afforded a tan solid as the hydrochloride salt of the title compound (35 mg, 99% yield). MS (ES+) m/z: 417.1 (M+H). LC retention time: 2.776 min (analytical LCMS Method J).

Provenance & Evidence